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I'll throw my 2¢ in here as I just had a similar situation the other day (on a 3.5L 300, but same issue.)

It had a 1, 3, 5 misfire code and, watching them, they'd miss and then go away and them miss again. Others had dealt with this by replacing coils, plugs and 3 PCMs with only a temporary change. When I got it, I swapped the injectors with no change, ran a leak down and a hot compression test and everything checked out good. I finally decided to pull the head and found the problem, all 6 exhaust valves were burnt!

The valves are designed to rotate to keep the face clean and it was fine until the burn mark on the valve and the burn mark on the seat lined up and then it'd misfire until the valve rotated past the bad spot. You could have a similar issue.

As others have said. A chain would effect all the cylinders, a camshaft would more than likely cause a constant, not intermittent, misfire, and you,ve replaced pretty much everything else. If it were me, I'd pull the head and check it out??

If it's in good shape otherwise, I say fix it and keep it.
 
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