It can be a performance gain when you start to free up more power through more air flow. Free flowing intake, headers, free flow cats (or cat delete) and an upgraded tune means more fuel use especially at WOT. The more efficiently the exhaust travels especially at high rpms, the freer the engine will run.
The mid suitcase pipe entrance is only 2 inches on the r/t. Both Kooks and American racing headers (the two most common Durango headers) use 3 in mid pipes. You can see where there can be some restriction in flow. I used ARH 3in cat back, which actually changes to 2.5 in at the small mufflers that sit under the rear differential/axels. Borlas and Corsas use 2.5 inch pipe all the way back past the mid pipes, which is more than enough for most. I'm doing a midrange cam on top of what I've already done, so I'm just trying to get the most out it I can when its done.
Not saying there are huge increases in HP with an exhaust change like a mid muffler delete. But it's about progression, everything added working together as a whole to squeeze out potential.